Avignon är en stad och kommun i departementet Vaucluse i regionen Provence-Alpes-Côte d’Azur i sydöstra Frankrike. Tidigare låg den i den historiska provinsen Provence. Redan under romartiden fanns här en betydande ort.
Between 1309 and 1377 during the Avignon Papacy, seven successive popes resided in Avignon and in 1348 Pope Clement VI bought the town from Joanna I of Naples. Papal control persisted until 1791 when, during the French Revolution, it became part of France. The town is now the capital of the Vaucluse department and one of the few French cities to have preserved its ramparts.
The historic centre, which includes the Palais des Papes, the cathedral, and the Pont d’Avignon, became a UNESCO World Heritage Site in 1995. The medieval monuments and the annual Festival d’Avignon have helped to make the town a major centre for tourism.
The commune has been awarded one flower by the National Council of Towns and Villages in Bloom in the Competition of cities and villages in Bloom.